Just over two hours northwest of New York City, YO1 is a wellness retreat that sits on 1,300 lush acres in the Catskills. At the resort, you can work under the guidance of experts to create your own wellness experience. Offerings include an Ayurvedic health center and health programs that address anxiety, stress, insomnia, infertility, and obesity, among others. The property also has a 68,000-square-foot health resort and plenty of outdoor space for hiking, practicing yoga, and enjoying nature.